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In DR, advanced glycation end-products (AGEs), products of hyperglycemia, interact with endothelial cells to stimulate VEGF production, which increases endothelial permeability by destabilizing TJs and promoting the degradation of GDNF, thus impairing barrier function [160]
It does not directly activate GLP-1 receptors the way semaglutide or tirzepatide do
Ipamorelin is a selective ghrelin receptor agonist that stimulates GH release through a complementary pathway without producing the cortisol and ACTH elevation seen with older secretagogues
The outer thigh usually has the least vascular area, and hence provides the least chance of bruising
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