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doi: 10.1038/s41586-020-2918-0 206 ObayanA
Mechanistically, DMSO is a cell-permeable reagent known to bind to various proteins in the cytoplasm or nucleus 8 , which directly (chemically and physically) interrupts their functions 9
For skin, glutathione is especially known for: Supporting the production of lighter pheomelanin over darker eumelanin, reducing hyperpigmentation
Glutathione itself is available as a compounded pharmaceutical ingredient, and licensed compounding pharmacies legally produce it for clinical use
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