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J Clin Endocrinol Metab, 91(3):799-805
Cetirizine is metabolized to a limited extent by oxidative O-dealkylation to a metabolite with negligible antihistaminic activity
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This reference shows that rapamycin activates the Akt pathway by a mechanism not originally anticipated that might be dependent on IGF1 signalling, providing a rationale for combination therapies involving rapamycin analogues and IGF1 and/or insulin receptor-targeting agents
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