The novel ATR inhibitor BAY 1895344 is efficacious as monotherapy and combined with DNA damage-inducing or repair-compromising therapies in preclinical cancer models
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While direct mutagenic effects were not identified in safety studies, proliferative effects were, representing a plausible pathway for increased risk of PDAC
Users of weight loss jabs are advised to eat a healthy, balanced diet focusing on protein (meat, fish, eggs, dairy, plant-based options), fibre-rich foods (vegetables, beans, whole grains), and healthy fats (nuts, seeds, avocado, olive oil), while limiting ultra-processed foods, refined carbs, sugary snacks, and alcohol