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the mechanisms of action may interact in unpredictable ways
Co-agonism, or tri-agonism, of separate therapeutic targets leverage strategic combinatorial synergism to amplify satiety, body-weight lowering and glucoregulatory benefits
doi: 10.1210/en.2010-0068 194 ToniN.TengE
Systems such as dual oxide antigen-captured nanosponges, self-cascade penetrating nanoflakes, and nanosponge-mediated dendritic cell modulation have demonstrated how structural optimization within complex immune microenvironments can achieve precise targeting and enhanced immunoregulatory activity [71,72,73,74]
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