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The drug actually has a long-standing FDA boxed warning that was reviewed in 2024 and remains a labeling formality, not a clinical concern at PCOS doses

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Our study did not specifically investigate the reasons for discontinuation, so further research would be needed to answer this question definitively. Bartelt added that health care providers should discuss the potential for weight regain after discontinuation with their patients and reiterate the importance of incorporating other weight management strategies, such as diet and exercise. Future research could focus on understanding the reasons for weight regain after discontinuation of these drugs and explore the long-term effects these drugs have on weight management and other side effects, she said

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