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These medications may have a direct impact on articular chondrocytes and other joint tissues, potentially improving cartilage health and reducing inflammation. As researchers drive toward this goal, early research in lupus and other conditions has offered mixed results

Using this platform, they demonstrated that Aurora kinase inhibitors (AURKi) induce senescence in diffuse-type gastric cancer (DGC) cells and promote secretion of MCP-1/CCL2, which remodels the immune microenvironment and skews macrophages toward an M2 phenotype, contributing to therapeutic resistance

Beyond the core signaling molecules, transcriptional regulation and neurodevelopment within this pathway are equally crucial