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For the annulus fibrosus (the outer ring of the disc made primarily of collagen), this mechanism may support healing of small tears and prevent further deterioration
Animal studies report effects on inflammatory markers in models of gastric ulcers, inflammatory bowel conditions, and various organ injuries
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This well-established importance underlies the role of vitamin B12 deficiency in mood imbalances, psychotic disorders, and neuronal health, particularly in elderly patients, where this deficiency is estimated to affect up to 40% of the population (25, 72)
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