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As noted earlier, the risk of inflammation and NDD is associated with T2DM and insulin resistance, which suggested that treatments that reduce the pathology of T2DM can also be successful in the treatment of neuroinflammation and NDD
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Most importantly, this protective phenotype appears to involve the following beneficial cellular adaptions: (i) enhanced metabolism of ethanol and acetaldehyde, (ii) suppression of lipogenic genes and induction of genes involved in fatty acid oxidation, and (iii) induction of the NRF2 antioxidant response and the AMPK metabolic signaling pathway
It is suggested that glutathione supplements might prove to be useful
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