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Shigeoka, S., Takeda, T., Hanaoka, T
Previous studies in myocardial ischemia have revealed that ischemia leads to a progressive loss of cholesterol from tissues and the sarcoplasmic and sarcoplasmic reticulum, accompanied by a significant increase in mitochondrial cholesterol content that is admixed explicitly to this membrane system [63]
Concurrently, genetic and epigenetic profiling is being incorporated into large-scale prospective studies to further clarify gene-environment interactions, identify biologically vulnerable subgroups, and build individualized risk models 29
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