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Rapid decreases can affect the hypothalamic-pituitary-ovarian axis [12] [13] Changes in body fat percentage : Particularly relevant when body fat drops below certain thresholds Caloric restriction effects : Even with adequate nutrition, significant energy deficits can temporarily suppress reproductive function Metabolic adaptation : The body may prioritise essential functions over reproduction during periods of rapid metabolic change For women taking GLP-1 medications , the weight loss achieved may be more rapid than with lifestyle changes alone, potentially increasing the likelihood of temporary menstrual disruption
The presence of insulin resistance, prediabetes, or metabolic syndromeall common in PCOSmay strengthen the case for prescription, but does not guarantee access
Papadopoli D, et al
Variability of glutathione during the menstrual cycle-due to estrogen effects on hepatocytes
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