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Start your intake How Tirzepatide Causes Digestive Side Effects Tirzepatide activates two hormone receptors: GLP-1 and GIP
In trials, retatrutide produced larger average weight loss (about 24.2% at 48 weeks versus roughly 20.9% for tirzepatide at 72 weeks)
This breadth may reflect the fundamental nature of the pathways being studied, such as endothelial function, cell migration machinery, and stress-response biology, rather than a single tissue-specific receptor mechanism
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