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Retatrutide (5mg-10mg), Triple Incretin Receptor Agonist Engineered Engagement of GLP-1, GIP, and Glucagon Receptors Introduction Engineered Engagement of GLP-1, GIP, and Glucagon Receptors Retatrutide is a synthetic 39-residue peptide engineered as a balanced agonist of three distinct class B G protein-coupled receptors: the glucagon-like peptide-1 receptor (GLP-1R), the glucose-dependent insulinotropic polypeptide receptor (GIPR), and the glucagon receptor (GCGR)

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doi: 10.1007/bf00577838 29 HansenLDeaconCFOrskovCHolstJJ

(2022) "Tirzepatide Once Weekly for the Treatment of Obesity" The New England Journal of Medicine, 387(3) 3