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Studies of similar medications show 50-70% of lost weight returns within 12-24 months of discontinuation
It is most effective for weight management when combined with lifestyle changes
In data comparing results from weeks 1-4 and 5-8 (with semaglutide dose doubling from 0.25mg/week to 0.5mg/week over that interval) a clear dose-sensitivity was seen in most measures: the beneficial impacts of the medication (measured by effect size) were greater at the higher dose
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