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It adversely affects brain homeostasis through BBB dysfunction and hyperthermia ( Various METH dosing paradigms significantly disturb endothelial TJ assembly by inducing downregulation, fragmentation, or redistribution of major TJ proteins, including claudin-5 and ZO-1, which are mediated by MMP-1 and MMP-9 peptidases

Autophagy has a significant role in determining skin color by regulating melanosome degradation in keratinocytes

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Researchers planning new work should review the most current literature directly, with attention to the gap between the older sleep claims and the open mechanistic questions