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We now have top line phase 3 data for retatrutide a triple (GIP, GLP-1, glucagon) agonist: At 40 weeks (efficacy estimand): ~16.8% weight loss ~1.9% A1c reduction We are entering a new phase: Multi-hormonal therapies Integrated obesity and diabetes care Precision approaches to cardiometabolic disease One pathway is not enough for a complex disease like obesity, and it is exciting to see a growing pipeline of therapies with distinct mechanisms

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