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Stop the struggle." - Craig Primack, MD, Obesity Medicine Physician, Hims & Hers To reduce the likelihood of weight regain when discontinuing treatment, experts recommend tapering the dose under medical supervision, consuming around 100 grams of protein daily, and incorporating bi-weekly strength training to preserve muscle mass and maintain a higher metabolic rate

When to seek specialist input: Inadequate response to first-line pharmacotherapy after 6 months Complex medical history (cardiovascular disease, psychiatric conditions) BMI 40 kg/m or 35 kg/m with significant comorbidities Considering any off-label or combination treatment Patient safety advice: Always discuss treatment options with your GP or obesity specialist before making changes

Takeaway: Patients may struggle with neuropsychiatric side effects

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