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6 and 7), indicating that metformin likely exerts at least part of its chondroprotective effects by activating the Nrf2 signaling pathway

Neuroprotection in the Central Nervous System Glutathione (GSH) plays a vital neuroprotective role in the central nervous system (CNS), primarily by regulating redox homeostasis, detoxifying electrophilic compounds, and modulating excitotoxic signaling pathways

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By understanding how GLP-1RAs influence mitochondrial function and stress responses in the eye, researchers can identify pathways and biomarkers that are also relevant in the heart, brain or other organs, and vice versa , promoting broader therapeutic applications and potentially reducing the time and cost of developing treatments for complex, multi-organ diseases