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It is not recommended in patients with liver cirrhosis by fear of inducing lactic acidosis.42 However, this complication was reported only in anecdotal cases, particularly with concomitant alcohol intake.43 The use of this drug for the treatment of simple steatosis and NASH with or without DM has yielded conflicting results
Patients should never combine tirzepatide, an injectable with dual actions as a GLP-1 RA and glucose insulinotropic polypeptide, with any GLP-1 RA because it may result in fatal hypoglycemia
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