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Ania Jastreboff, MD, PhD, Yale School of Medicine, lead author of SURMOUNT-1 [1] This dual-action approach is why providers frequently prescribe them together rather than individually

The cell receptor for REV-1 is chemokine-like receptor 1 (chemR23 or CMKLR) (135), with the ligand-receptor interaction triggering anti-inflammatory responses that include marked inhibition of proinflammatory cytokines and chemokines (136)