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GLP-1 receptors are expressed in reward-related regions, such as the nucleus accumbens (NAc) and ventral tegmental area (VTA), where they influence dopaminergic signaling [43]
On the other hand, reliance on drugs could inadvertently discourage preventive measures (diet, exercise)
Zhang L et al
However, sustained high levels of circulating insulin may conversely exert a negative influence on cognitive function, due to prolonged peripheral hyperinsulinemia down-regulates insulin receptors at the blood-brain barrier (BBB) and reduces insulin transport into the brain, leading to brain insulin resistance (BIR) (1719)
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