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As a key methyltransferase of m6A, METTL3 can inhibit the activation of pTHP-1 macrophages by preventing the generation of IL-6 and TNF-, and attenuate inflammatory response induced by LPS via the NF-B signaling pathway (178)
These results have not been replicated in human clinical trials, so it is unclear whether these effects translate to human patients
*J Appl Physiol.* 110(3):774-780
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