International Journal of Clinical Pharmacology Research
in turn, vitamin C can restore glutathione, allowing both to continue protecting cells
The insulin resistance in PCOS might also occur independently of body weight, due to inherited post-receptor defects in insulin signalling that affects metabolism and mitotic pathways, not only in classic insulin target tissues, such as skeletal muscle, liver, and adipose tissue, but also in the non-classical target tissues, such as pituitary and ovary [12, 16]
Specifically, the Patient Health Questionnaire (PHQ-9) score for depression dropped significantly from 13.03 to 9.84, and the Fibromyalgia Impact Questionnaire (FIQ) score dropped from 49.55 to 43.03