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There is no difference in glucose reduction compared to the add-on of GLP1-RAs first or the SGLT2is first

rxlist.com (Brimonidine) drugs.com (Brimonidine) drugs.com (Brimonidine topical) Keywords Clonidine Trade Name: Catapres, Catapre-TTS, Duraclon Drug Class: Alpha-2 Selective Adrenergic Agonist Mechanism of Action: Central Sympatholysis ( Clonidine acts as an agonist at centrally located 2A Agonist): 2 -adrenergic receptors (particularly the 2A subtype) within the vasomotor center of the medulla oblongata, including the nucleus tractus solitarii (NTS) and lateral reticular nucleus (Gillis et al., 1985

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Abbreviations AP-1, activator protein 1