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& Holoubek, I
Bias in meta-analysis detected by a simple, graphical test
It urged health professionals to advise patients about the dangers of unregistered GLP-1 products and to discuss safer treatment options if patients have obtained weight-loss medicines online or from overseas suppliers
The mechanistic interpretation, debated for two decades, was that GIPR agonism did two things: it contributed to appetite suppression and energy expenditure in addition to GLP-1R activation, and - separately - it appeared to improve tolerability by reducing GLP-1-mediated nausea and GI adverse events
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