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However, over-supplementation can cause side effects, even though B12 is a water-soluble vitamin and excess amounts are typically excreted in the urine
If you dont feel the pierce of the needle, that helps significantly
Sato Y, Yamaguchi Y, Kawamoto T, et al
Titration: There is generally no need for upward titration with B-complex vitamins as one might do with certain drugs, but if a patient is frail or known to react to injections, the provider may choose to start at a lower dose (for example 0.25-0.5 mL) and then increase to 1 mL as tolerated
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