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Avery, A
In prepubertal female rats, a cerebroventricular infusion of IGF1 stimulated the secretion of GnRH and might advance the onset of puberty [15, 18]
Women using oral contraceptives should be counseled about this potential interaction and may need to consider alternative or additional contraceptive methods, particularly during the initial weeks of treatment when gastric emptying effects may be most pronounced
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