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Long-term studies on high-dose IV use are still limited, but no serious adverse effects have been documented in short-term studies

Conclusion In conclusion, this systematic review and meta-analysis highlighted that GTE supplementation significantly decreased BM, BMI, BFP, and MDA, while increasing TAC and adiponectin

The causal role of gut microbiota in PCOS pathogenesis has been further substantiated by animal studies demonstrating that fecal microbiota transplantation from PCOS patients to healthy mice recapitulates core disease manifestations, including anovulation and metabolic dysfunction (20, 21)

In general, there is an age-related increase of 5hmC levels in the brain, pointing towards a role for 5hmc in the development of AD [136, 149, 150]