does low glutathione cause autism Oxidative Stress Indicated by Nuclear Transcription Factor Nrf2 and Status in the Blood of Young Children with Spectrum Disorder: Pilot Study Concept of neuron glial interaction

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However, a dysregulated increase in the level of these free radicals, as seen in mitochondrial diseases, can result in oxidative damage by overwhelming the cellular antioxidant defence mechanism, of which glutathione is the principal component [4]

So, at least its positive with that

IR impairs mitochondrial substrate utilization, shifting energy metabolism from glucose oxidation toward fatty acid oxidation, which increases ROS production and reduces oxidative phosphorylation efficiency