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In pancreatic KRAS-mutated cancer cells, which can proliferate using albumin as the extracellular source of leucine, loss of SLC38A9 or its transport function strongly inhibited mTORC1 activation by macropinocytosed albumin as evidenced by cell proliferation and tumor formation (Goberdhan et al., 2016

[11] [3] Zepbound carries a Boxed Warning for risk of thyroid C-cell tumors

Fatty acid synthase inhibitors cerulenin and C75 retard growth and induce caspase-dependent apoptosis in human melanoma A-375 cells