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In addition, GLP-1RAs, reduce pancreatic islet -cell apoptosis, stimulate the proliferation and differentiation of -cells, and decrease body weight by suppressing food intake in patients with T2DM [8, 41,42,43]
doi: 10.1038/nri.2016.70 70 MillsELKellyBLoganACostaASHVarmaMBryantCEet al
The phase 2 trial showed that the 12mg group lost 24.2% of body weight at 48 weeks versus 8.7% in the 1mg group
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