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As a result of insulin resistance, downstream signal transduction is inhibited, but GSK3 still exists in its active state and hyperphosphorylates a number of substrates, including Tau protein, in nerve cells
Notably, some muscle groups, especially the rectus abdominis, psoas major, and paraspinal muscles, reportedly showed more evident changes
Lower right panel : comparison of scopolamine with atropine, emphasizing greater CNS penetration and effects of scopolamine at therapeutic doses, including sedation and memory impairment, versus the relatively limited CNS activity of atropine, which is more associated with restlessness and confusion at higher doses
OZ just from the fat
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