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doi:10.1002/14356007.a02_269.pub2
Discovered in 1973 by biochemist Loren Pickart in human blood plasma, this copper-tripeptide has been the subject of over five decades of research that has progressively revealed the breadth of its biological functions
Increased expression of DAF-16, the ortholog of human FoxO proteins in the worm Caenorhabditis elegans , due to a mutation of the insulin/IGF-1 receptor daf-2 has been found to significantly increase the worm's lifespan [2, 3]
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