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Mice with a homozygous null mutation for the most abundant glutathione peroxidase, Gpx1, show increased susceptibility to the oxidative stress-inducing agents paraquat and hydrogen peroxide
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Contact your GP or healthcare provider if you experience: Palpitations : Awareness of rapid, forceful, or irregular heartbeat, particularly if persistent or distressing Chest discomfort : Any chest pain, pressure, or tightness, especially with exertion Breathlessness : Unusual shortness of breath, particularly if worsening or occurring at rest Dizziness or lightheadedness : Especially if associated with near-fainting episodes Fatigue : Marked, unexplained tiredness that interferes with daily activities Persistent vomiting or diarrhoea : Which could lead to dehydration and kidney problems If you're unsure whether you need urgent care and cannot contact your GP, call NHS 111
Two recent studies that included individuals with and without type 2 diabetes found that GLP-1 contributed ~50% of the glucose-lowering and insulin-stimulatory effects of DPP-4 inhibitors [2, 18]
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