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Similarly, the SURMOUNT trials evaluating tirzepatide for weight management did not report increased rates of panic symptoms compared to placebo, though it's important to note that panic symptoms were not prespecified outcomes in these studies
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Sitagliptin demonstrates selectivity for DPP-4 and does not inhibit DPP-8 or DPP-9 activity in vitro at concentrations approximating those from therapeutic doses
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