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Although changes in the gut microbiome from calorie restriction have been studied, their direct role in human physiology remains to be fully described 28

Effectiveness of anti-obesity medications approved for long-term use in a multidisciplinary weight management program: a multi-center clinical experience

However, long-term use of Semaglutide can cause side effects such as nausea, vomiting, diarrhea, constipation, and headache