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At non-toxic concentrations of 1 to 10 nM, the peptide stimulates in preclinical models both the synthesis and the breakdown of collagen and glycosaminoglycans such as dermatan and chondroitin sulfate as well as decorin, and it modulates matrix metalloproteinases together with their inhibitors TIMP-1 and TIMP-2

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Patient can have maximum 2 sessions in a week

During this time period, the simulation length and the constituents in the simulation domain were increased with better computational facilities and MD simulation codes