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That is why it can be swallowed at all, and why it behaves like a small-molecule drug: real oral absorption, first-pass liver metabolism, a huge volume of distribution (39 L/kg in mice), and off-target enzyme binding
Practical solutions include protein shakes (30 to 50 grams per shake), Greek yogurt, cottage cheese, protein-first eating (always eat the protein on your plate before anything else), and strategic meal timing
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