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Zeissig S, Brgel N, Gnzel D, Richter J, Mankertz J, Wahnschaffe U, Kroesen AJ, Zeitz M, Fromm M, Schulzke JD: Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease
For instance, during the early phases of acute myocardial infarction, the acute onset of high-grade local inflammation is revealed not only by the polymorphonuclear neutrophils activation and recruitment of mononuclear cells but also by the local release of pro-inflammatory molecules such as IL-1 and IL-6 [118]
D., Kramer N
Figure 4 Alterations in the intracellular redox status are often associated with GSH depletion (Polonikov, 2020) and endogenous GSH deficiency, due either to decreased biosynthesis and/or increased consumption, is a marked contributor to the pathogenesis of numerous diseases via mechanisms including oxidative stress and inflammation
