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For instance, the nitric oxide reductase NorB and the cytochrome c (CycP) detoxified NO produced by macrophages (Stevanin et al., 2005), while PorB-TLR2 interaction enhances anti-inflammatory IL-10 production (Samarasinghe et al., 2006) and modulates Nf-B signaling (Oliveira-Nascimento et al., 2012), reprogramming dendritic cells toward a Th2 response (Mukherjee et al., 2016)

10.1016/S2468-2667(21)00249-8 Lancet Public Health 27 GrimmigB.DalyL.SubbarayanM.HudsonC.WilliamsonR.NashK.et al (2018)

Stacking with other experimental peptides (like AOD-9604) is speculative and not clinically tested

10.1126/science.aaw5473 77 FaubertB.VincentE