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At clinical doses under supervision, the most common side effects are mild nausea in the first week (typically resolves by day 7 to 10), injection site reactions (redness, minor swelling, localized soreness lasting 24 hours), and occasional transient fatigue or mild headache in the first few days

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Evidence is strongest mechanistically and in wound/repair context not erase wrinkles in 14 days. ( MDPI ) Topical use is where it makes sense for therapists