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Given that NOX and NOS activity in neutrophils and macrophages depend upon G6PD-derived NADPH and reduced glutathione (GSH) (7), the role of G6PD and the PPP has been studied in these cell types, and roles for G6PD activity have been identified even beyond the oxidative burst
In contrast, furin, a membrane-bound protease present in the Golgi apparatus, may be involved in cleaving S protein during biosynthesis 11
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Grebe, A., Hoss, F
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