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In the digestive system, Semaglutide delays gastric emptying significantly

Although redressing the BA composition has proved to be beneficial in mouse models, it was unlikely to translate to human pathophysiology, as changes in BA composition in mice hardly reflect similar changes in BA profiles in humans due to the differences in BA composition 41

The article explains that these medications act in the hypothalamus, pancreas and gastrointestinal tract, so decisions have to account for renal function, cardiovascular history, diabetes status and prior medication responses

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