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The cadmium in nicotine lowers the effectiveness of antioxidants like vitamins C and E, and glutathione, and reduces hormone production, including serotonin and melatonin
Indeed, the interconversion of serine and glycine, via the involvement of THF, represents a major pathway for the generation of 5,10-methylene-THF which is a member of the active folate pool
Furthermore, we found that the response of PC to GSH-targeted treatment is largely determined by stratified expression of VRK2, which provides a theoretical basis for individualized therapy targeting metabolism
Thus, cystine is the primary amino acid which regulates cellular GSH homeostasis in HepG2 cells
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