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In-vitro skin diffusion studies demonstrated a 5-fold increase in glutathione deposition compared to the free drug control
This hyper-proliferative state drains the body's metabolic energy and drives the profound fatigue seen in these conditions
Moreover, in fresh samples from patients who underwent neoadjuvant chemotherapy, the GSH/GSSG levels in the resistant group were significantly higher than those in the sensitive group, which is consistent with previous research [28]
Due to the presence of protonated amino groups carrying a positive charge, CS exhibits pH-regulating properties and functions as a water-soluble cationic polyelectrolyte capable of interacting with negatively charged molecules
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