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It also modulates the release of glutamate, D-serine and ATP from astrocytes 99

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Furthermore, IGF-1 decreased vascular expression of the proinflammatory cytokines interleukin-6 and tumor necrosis factor-, reduced aortic superoxide formation and urinary 8-isoprostane levels, and increased aortic pAkt and eNOS expression and circulating endothelial progenitor cells, consistent with an antiinflammatory, antioxidant, and prorepair effect on the vasculature. Restored Insulin Sensitivity In a 2010 study, lower IGF levels were associated with diabetes