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The Nitric Oxide Pathway L-Citrulline works through the following pathway: [4] When consumed, L-citrulline bypasses the liver's first-pass metabolism and enters the bloodstream efficiently
So the way it does this is by activating a gene called UCP-1, uncoupling protein 1, norepinephrine is upstream of that, activating it
Supported by progress in targeted delivery systems, these multifaceted mechanisms underscore its significant potential for clinical application (80)
10.3389/fcvm.2022.1019120 80
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