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Bioavailability concerns : Many plant compounds require digestive processing and liver metabolism to become bioactive, processes that are bypassed with transdermal delivery
User 15 cited a general dosing range of 2.5 to 3.75mcg per kilogram of body weight twice daily, which, at higher body weights, still produces doses within the standard 250 to 500mcg range being used across the dataset
May assist in weight management in adults who are overweight or obese and have at least one weight-related condition (such as hypertension, type 2 diabetes, or high cholesterol) 4 , 22
Its primarily beneficial for nondiabetic overweight or obese adults
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