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Indeed, it has been estimated that just 10-15% of the secreted GLP-1(7-36) NH2 reaches the systemic circulation (117), with some authors reporting meager peripheral meal-induced changes in both healthy and diabetic people (118)
doi: 10.3389/fmed.2026.1783429 Received 10 January 2026 Revised 20 April 2026 Accepted 30 April 2026 Published 28 May 2026 Volume 13 - 2026 Edited by Achuthan Raghavamenon, Amala Cancer Research Centre, India Reviewed by Raffaele Carraro, La Princesa University Hospital, Spain Theodoros Androutsakos, National and Kapodistrian University of Athens, Greece Updates Copyright 2026 Wu, Zhang, Ye, Chen, Tung and Zhu
Semaglutide and dulaglutide were classified as early failure types, exenatide as a random failure type, and liraglutide as a wear-out failure type (Additional file 1: Table S5 for raw data)
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