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Some peptides may influence hormonal pathways, particularly those involving melanocortin receptors in the central nervous system, which play a role in sexual arousal and erectile function

In their separate Phase 2 trials, retatrutide monotherapy showed larger weight loss (~24.2% at 48 weeks, 12 mg) than standalone cagrilintide (~10.8% at 26 weeks, 4.5 mg), and indirect network meta-analyses rank retatrutide highly

Because retatrutide is not currently licensed in the UK, the most important safety message is straightforward: this medication should not be self-administered outside of an approved clinical trial or a formal MHRA access scheme (such as the Early Access to Medicines Scheme [EAMS] or named-patient unlicensed supply) overseen by a qualified medical team

For a 55-year-old already on a blood pressure medication, that means a meaningfully higher fall risk